Chronic Activation of PPARα with Fenofibrate Prevents Alterations in Cardiac Metabolic Phenotype without Changing the Onset of Decompensation in Pacing-Induced Heart Failure

نویسندگان

  • Volodymyr Labinskyy
  • Michelle Bellomo
  • Margaret P. Chandler
  • Martin E. Young
  • Vincenzo Lionetti
  • Khaled Qanud
  • Federico Bigazzi
  • Tiziana Sampietro
  • William C. Stanley
  • Fabio A. Recchia
چکیده

Department of Physiology, New York Medical College, Valhalla, NY 10595 (V.L., M.B., K.Q., F.A.R.); Sector of Medicine, Scuola Superiore Sant’Anna, Pisa, Italy (V.L., F.A.R.); Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX (M.E.Y.); Institute of Clinical Physiology, CNR, Pisa, Italy (V.L., F.B., T.S.); Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH (M.P.C., W.C.S.) JPET Fast Forward. Published on January 10, 2007 as DOI:10.1124/jpet.106.116871

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Endothelin-1-Induced Cell Hypertrophy in Cardiomyocytes is Improved by Fenofibrate: Possible Roles of Adiponectin

AIM Previous studies demonstrated that endothelin-1 (ET-1) can significantly increase the cell size and stimulate adiponectin expression in cultured human cardiomyocytes (HCM). The aim of the present study was to investigate the effects of fenofibrate, a peroxisome proliferator-activated receptor-α (PPARα) activator, on cell hypertrophy and adiponectin expression in vitro and in a rat model of ...

متن کامل

PPARα activation by fenofibrate protects against acute myocardial ischemia/reperfusion injury by inhibiting mitochondrial apoptosis

Peroxisome proliferator-activated receptor α (PPARα) is highly expressed in heart, but its metabolic regulation effect in rats with myocardial ischemia/reperfusion injury is still a controversy. In this study, the cardioprotective effect of PPARα activation in rats with myocardial ischemia/reperfusion injury and its relevant mechanism was investigated. Adult male Wistar rats were pretreated wit...

متن کامل

Modulation of fatty acid metabolism is involved in the alleviation of isoproterenol-induced rat heart failure by fenofibrate

Heart failure is a disease predominantly caused by an energy metabolic disorder in cardiomyocytes. The present study investigated the inhibitory effects of fenofibrate (FF) on isoproterenol (ISO)‑induced hear failure in rats, and examined the underlying mechanisms. The rats were divided into CON, ISO (HF model), FF and FF+ISO (HF animals pretreated with FF) groups. The cardiac structure and fun...

متن کامل

Lipopolysaccharide Induced Activation of Toll Like Receptor 4 in Isolated Rat Heart Suggests a Local Immune Response in Myocardium

Background: Myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. In many cases of sepsis, the presence of Lipopolysaccharide (LPS) has been established. LPS Binding Protein (LBP) bound endotoxin is recognized by CD14/toll-like receptor-4 (TLR4) complexes in inna...

متن کامل

A journey in doxorubicin-induced cardiotoxicity with emphasizing on the role of Connexin 43 and Sirtuin-3

Cancer has become a major health problem worldwide. The reported incidence of new cancer cases is estimated at 19.3 million, with a mortality rate of 10 million in the world in 2020. There are some approaches for cancer treatment such as chemotherapy, neoadjuant surgery, hormone therapy, and radiotherapy. Chemotherapy is an aggressive form of chemical drug therapy meant to destroy rapidly growi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2007